Biological tissue freeze-drying technology

  Biological tissue materials are frozen and dry and their preparation methods are biotechnology.

  Background technique:

  Biomass materials are used for contact and interaction with the life system, and can be used for the diagnosis, repair and enhancement of human tissue and organs, that is, the natural or natural or regeneration of replacement, repair or induce regeneration Special functional materials for artificial synthesis are irreplaceable. For example, in the treatment of cardiac surgery, in most cases, various types of repair materials need to be implanted to replace the tissue organs with alternative lesions to restore its functions. Biomatical materials include artificial synthetic materials and natural materials, as well as hybrid materials made of single materials, composite materials, and active cells or natural tissues or life -free materials.

Biological tissue freeze-drying technology


  Cardiac valve disease is a common valve recession. At present, 10 to 20 % of the heart valve replacement surgery in my country is biological flap replacement. Compared with mechanical petals, the advantages of biological petals are that they do not need to take anticoagulant drugs for life, which greatly improves the quality of life after surgery. In addition, with the promotion of involvement of valve replacement surgery, the demand for intervention in biofiles has increased. However, the requirements for intervention in biofiles for material treatment are higher than that of ordinary biological valves. Therefore, the treatment of biological materials to improve its anti -calcification ability and biocompatibility, which is of great significance for the development of the medical field and the quality of life after surgery.

  At present, the modification of biological materials is often made to reduce its immunogenicity, improve its degradation, and improve its physical and mechanical properties. At this stage of the modification of biomass materials, mitochiatal aldehydes have been used. The aldehyde molecules contain two aldehydes of reactive activity, which can form covalent cross -linked between biomae molecules to effectively reduce the immuneness of biomass materials and improve its degradation resistance. This method was first used by the French Carpentier for the treatment of cardiac valve materials for the first time. The use of this method to treat biomass materials can also achieve the effects of cross -linking tissue, removing immunity, increasing stability, and disinfection.

  The development of biomass materials into a dry state for preservation of the aldehyde solution is pre -compressed and loaded in the biomass transport system in advance, which can better solve the above problems. Bio -material preservation has lower requirements for preservation, longer storage time, and the ability to withstand poor environment. At the same time, it can be used directly after the whole packaging of biomass materials preserved in a dry form. It does not need to be washed and assembled. It is more convenient to apply and save rescue time. However, because the dry biomass materials are pre -loaded in the biomass transportation system need to withstand a long period of mechanical compression and prone to compression damage, higher requirements are made for the toughness of the biological material under the dry loading state. The toughness of existing biomass is still insufficient. The above -mentioned defects also largely restrict the further clinical application of existing biomass materials.

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